Frequency distribution patterns of HLA antigens, genes, and haplotypes in the migrant population of the northwestern Russia in relation to time of residence in the region and sex differentiation

Frequency distribution patterns of the HLA antigens, genes, and haplotypes at subloci A, B, and Cw were examined in 664 female and 765 male Slavs in d ependence to the duration of their residence in the extreme conditions of t he Magadan region. In the groups studied, no statistically significant diff erences in the frequencies of the corresponding genes and antigens were fou nd. Analysis of gamete associations showed that positive and negative assoc iations revealed in some cases were typical of the population of the region on the whole. However, a sex-dependant association, as well as that depend ant on the duration of residence in extreme conditions, were also establish ed.