Comparative analysis of nucleotide sequences of chromosomal DNA isolated from nuclear envelopes and cores of rosette-like structures of murine interphase chromosomes
Mv. Glazkov et al., Comparative analysis of nucleotide sequences of chromosomal DNA isolated from nuclear envelopes and cores of rosette-like structures of murine interphase chromosomes, RUSS J GEN, 35(2), 1999, pp. 209-213
Six DNA fragments of interphase chromosomes isolated from nuclear envelopes
of murine hepatocytes were cloned and sequenced. Analysis of their structu
ral-functional organization suggests that these fragments are highly specif
ied protein-noncoding fractions of a eukaryotic genome. In evolution, they
appear already in archaebacteria and may be "ancestral" for DNA sequences i
nvolved in structuring chromosomal domains (rosette-like structures) of tis
sue-specific genes. In their composition, these fragments have nucleotide s
equences homologous to the repeats of the SINE and LINE families and to the
satellite DNA of murine centromeres.