Comparative analysis of nucleotide sequences of chromosomal DNA isolated from nuclear envelopes and cores of rosette-like structures of murine interphase chromosomes

Six DNA fragments of interphase chromosomes isolated from nuclear envelopes of murine hepatocytes were cloned and sequenced. Analysis of their structu ral-functional organization suggests that these fragments are highly specif ied protein-noncoding fractions of a eukaryotic genome. In evolution, they appear already in archaebacteria and may be "ancestral" for DNA sequences i nvolved in structuring chromosomal domains (rosette-like structures) of tis sue-specific genes. In their composition, these fragments have nucleotide s equences homologous to the repeats of the SINE and LINE families and to the satellite DNA of murine centromeres.