A medical genetic description of two district populations of Krasnodar krai

The spectrum and prevalence rate of hereditary pathology in Kanevskii and B ryukhovetskii raions (districts) of Krasnodar krai (territory) were analyze d. The total size of the studied population was 145 937. The prevalence rat e of monogenic hereditary pathology was estimated. This value was 1.08 +/- 0.08, 0.72 +/- 0.07, and 0.20 +/- 0.06 per 1000 people for autosomal domina nt (AD), autosomal recessive (AR), and X-linked (XL) recessive diseases, re spectively. Forty-two AD (158 affected persons in 82 families), 32 AR (105 affected persons in 82 families), and 6 XL disease entities (13 affected pe rsons in 8 families) were found. A slight genetic subdivision was found in the populations of Kanevskii and Bryukhovetskii raions. However, it was not found to affect the prevalence of hereditary pathology.