We consider four aspects of interstellar chemistry for comparison with come
ts: molecular abundances in general, relative abundances of isomers (specif
ically, HCN and HNC), ortho/para ratios for molecules, and isotopic fractio
nation, particularly for the ratio hydrogen/deuterium. Since the environmen
t in which the solar system formed is not well constrained, we consider bot
h isolated dark clouds where low mass stars may form and the "hot cores" th
at are the sites of high mass star formation. Attention is concentrated on
the gas phase, since the grains are considered elsewhere in this volume.