Use of different cellulose derivative for the preparation of tablets with a high active agent content

Metronidazole tablets were prepared and the morphological and powder, rheol ogical parameters of metronidazole were tested. It was concluded that the f low properties of the crystals were unsuitable, and wet granulation was the refore preferred as the tablet manufacturing method. Different cellulose de rivatives (hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl m ethylcellulose, methylhydroxy ethylcellulose) were chosen as binders. Granu lation was performed with a fluid bed apparatus, and tableting with ail ecc entric tablet machine. The physical parameters of tablets and dissolution o f the drug were rested. It was concluded that the best physical parameters and dissolution were achieved with tablets prepared using hydroxypropyl cel lulose (Klucel LF) at 10 kN.