Solid phase synthesis of 1,3-disubstituted succinimides

Authors
Alvarez-Gutierrez, JM Nefzi, A Houghten, RA
Citation
Jm. Alvarez-gutierrez et al., Solid phase synthesis of 1,3-disubstituted succinimides, TETRAHEDR L, 41(5), 2000, pp. 609-612
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
5
Year of publication
2000
Pages
609 - 612
Database
ISI
SICI code
0040-4039(20000129)41:5<609:SPSO1S>2.0.ZU;2-9
Abstract
The solid phase synthesis of N-substituted succinimides is described. The s trategy used is based on the intramolecular cyclization of a dipeptide cont aining aspartic acid in the second position promoted by diphenylphosphoryla zide (DPPA) and triethylamine. Large numbers of succinimides can be prepare d using different, commercially available building blocks. (C) 2000 Elsevie r Science Ltd. All rights reserved.