Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones

Authors
Renault, O Guillon, J Dallemagne, P Rault, S
Citation
O. Renault et al., Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones, TETRAHEDR L, 41(5), 2000, pp. 681-683
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
5
Year of publication
2000
Pages
681 - 683
Database
ISI
SICI code
0040-4039(20000129)41:5<681:ESO2>2.0.ZU;2-5
Abstract
Syntheses of 2-aryl-6-methyl-2,3-dihydra-1H-pyridin-4-ones were achieved st arting from corresponding beta-aryl-amino acids. This reaction sequence inv olved, as a key step, the condensation of an acid chloride with a diketone using SmI3 as catalyst. A final intramolecular cyclization furnished the at tempted product. (C) 2000 Elsevier Science Ltd. All rights reserved.