Amphidinolide V, novel 14-membered macrolide from marine dinoflagellate Amphidinium sp.

Authors
Kubota, T Tsuda, M Kobayashi, J
Citation
T. Kubota et al., Amphidinolide V, novel 14-membered macrolide from marine dinoflagellate Amphidinium sp., TETRAHEDR L, 41(5), 2000, pp. 713-716
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
5
Year of publication
2000
Pages
713 - 716
Database
ISI
SICI code
0040-4039(20000129)41:5<713:AVN1MF>2.0.ZU;2-T
Abstract
A novel 14-membered polyene macrolide, amphidinolide V (1), has been isolat ed from a marine dinoflagellate Amphidinium sp., and the structure was eluc idated by spectroscopic data. The relative stereochemistry of C-8, C-9, C-1 0, and C-13 was elucidated by NOESY correlations. Amphidinolide V (1) posse ssing five exo-methylenes and one epoxide exhibited cytotoxicity against tu mor cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.