Base catalysed rearrangement of fluocinolone acetonide to a 17 alpha-pregnane-21,16 alpha-carbolactone

Authors
Procopiou, PA Irving, WR Lynn, SM Richards, SA
Citation
Pa. Procopiou et al., Base catalysed rearrangement of fluocinolone acetonide to a 17 alpha-pregnane-21,16 alpha-carbolactone, TETRAHEDR L, 41(5), 2000, pp. 767-770
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
5
Year of publication
2000
Pages
767 - 770
Database
ISI
SICI code
0040-4039(20000129)41:5<767:BCROFA>2.0.ZU;2-F
Abstract
Treatment of fluocinolone acetonide with sodium hydride in DMF gave the 6 a lpha,9 alpha-difluoro-11 beta,20 beta-dihydroxy-3-oxo- 17 alpha-pregnane-1, 4-diene-21,16 alpha-carbolactone in high yield. (C) 2000 Elsevier Science L td. All rights reserved.