N. Kroger et al., Efficacy of further attempts to mobilize CD34+peripheral stem cells with alternative procedures after primary failure, ACT HAEMAT, 102(3), 1999, pp. 144-147
19 patients who failed the target collection of at least 2.5 x 10(6) CD34cells/kg underwent further mobilization procedures either with granulocyte-
colony-stimulating factor (G-CSF) alone after failure to chemotherapy plus
G-CSF (group 1), or with chemotherapy plus G-CSF (group 2), or with high-do
se G-CSF (24 mu g/kg) alone (group 3) after failure to respond to standard
dose of G-CSF(10 mu g/kg) alone. In all groups, an increase in median CD34 cell yield could be observed following alternative procedures (1.1- to 1.9
x 10(6) kg; p = 0.02). The highest increase in CD34+ cell harvest was achi
eved in group 1 (0.85 to 2.2 x 10(6) kg), followed by group 2 (1.2 to 1.7)
and group 3 (1.0 to 1.4), but without statistically significant difference
between the mobilization technologies. All patients with more than 1.0 x 10
(6) CD34+ cells/kg in the first apheresis procedure reached the overall tar
get of 2.5 x 10(6) CD34+ cells/kg after a second or subsequent mobilization
procedure. In contrast, only 3 of 8 patients (37%) with less than 1.0 x 10
(6) CD34+ cells in the first harvest could reach the target of 2.5 x 10(6)
CD34+ cells after further mobilization attempts. Copyright (C) 2000 S. Karg
er AG, Basel.