The use of vesicles as templates for the polymerization of inserted monomer
s gives rise to novel vesicle-polymer hybrid morphologies where a polymer b
ead is phase-separated from the vesicle bilayer matrix. Complex vesicle-pol
ymer architectures, such as the "wrapped parachute" morphologies shown in t
he Figure, are synthesized here and then examined using cryo-transmission e
lectron microscopy (see also cover).