Heterogeneity in Wiedemann-Beckwith syndrome: Anthropometric evidence

Wiedemann-Beckwith syndrome (WBS) has attracted a great deal of attention b ecause of its genetic complexity. Individuals with WBS can be identified ob jectively by anthropometric analysis. Craniofacial anthropometry in conjunc tion with multivariate statistical analysis can be used to define patterns of variability that appear to relate to specific modes of inheritance that have been proposed for WBS. Our data on 19 affected individuals and their f irst-degree relatives indicate that the pattern of inheritance rather than the age of subjects may be responsible for the highly variable craniofacial phenotype found in individuals diagnosed with WBS. Am. (C) 2000 Wiley-Liss , Inc.