Percutaneous coronary interventions in patients with prior coronary arterybypass surgery: Changes in patient characteristics and outcome during two decades
V. Mathew et al., Percutaneous coronary interventions in patients with prior coronary arterybypass surgery: Changes in patient characteristics and outcome during two decades, AM J MED, 108(2), 2000, pp. 127-135
Citations number
41
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
PURPOSE: Patients who develop recurrent myocardial ischemia after coronary
artery bypass graft (CABG) surgery are often referred for percutaneous coro
nary interventions. The objective of this study was to evaluate the changin
g demographic and clinical characteristics, and procedural and long-term ou
tcomes, in patients with prior CABG referred for percutaneous coronary inte
rventions during a 20-year period.
METHODS: We prospectively collected data on patients who underwent coronary
interventional procedures following CABG surgery. We compared angiographic
and procedural success, and long-term event-free survival, among patients
who had procedures from 1979 to 1989 (n = 393), from 1990 to 1994 (n = 811)
, and from 1995 to 1998 (n = 937).
RESULTS: Patients in the 1995 to 1998 cohort were older, had a lower mean l
eft ventricular ejection fraction, and were more likely to have diabetes, h
ypertension, and hyperlipidemia, but less likely to smoke. They were more l
ikely to have treatment of complex lesions, including vein graft lesions, a
nd had more prior CABG surgeries. More patients received intracoronary sten
ts in 1995 to 1998. Both angiographic success rates (78% from 1979 to 1989,
88% from 1990 to 1994, and 91% from 1995 to 1998, P <0.0001) and procedura
l success rates (78%, 86%, and 91%, P <0.0001) improved with time. Long-ter
m mortality was greater in the pre-1990 group (relative risk = 1.8, 95% con
fidence interval: 1.3 to 2.4) and 1990 to 1994 group (relative risk = 1.7,
95% confidence interval: 1.3 to 2.2) compared with the 1995 to 1998 group,
as were the likelihoods of repeat revascularization and recurrent severe an
gina.
CONCLUSION: Although the demographic and clinical characteristics of patien
ts who underwent percutaneous intervention following CABG surgery indicate
that they are at increasingly greater risk of adverse cardiac events, succe
ss rates and long-term survival have improved with time. The rates of recur
rent severe angina as well as of subsequent revascularization have also dec
reased, probably as a result of improvements in technique and greater use o
f stents and adjunctive medications. (C) 2000 by Excerpta Medica, Inc.