Factors influencing resistance to reinfection with Plasmodium falciparum

Citation
O. Domarle et al., Factors influencing resistance to reinfection with Plasmodium falciparum, AM J TROP M, 61(6), 1999, pp. 926-931
Citations number
31
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
61
Issue
6
Year of publication
1999
Pages
926 - 931
Database
ISI
SICI code
0002-9637(199912)61:6<926:FIRTRW>2.0.ZU;2-V
Abstract
A treatment-reinfection study design was used to investigate the relationsh ips between host immunologic and/or genetic factors and resistance to reinf ection with Plasmodium falciparum. Sixty-one children in Gabon were enrolle d in a cross-sectional study to measure the prevalence of each human plasmo dial species. All were given amodiaquine for radical cure of parasites, and 40 were subsequently followed-up for 30 weeks. Successive blood smears wer e examined to measure the delay of reappearance in blood of asexual stages of P. falciparum parasites. Presence of infection during the cross-sectiona l survey was associated with male sex, non-deficient glucose-6-phosphate de hydrogenase activity, plasma interleukin-10 level, and anti-LSA-Rep antibod y concentration. Resistance to reinfection was related to the presence of a nti-LSA-J antibodies, and the absence of anti-LSA-Rep antibodies. Moreover, P. malariae-infected subjects were usually co-infected with P. falciparum, and were also more rapidly reinfected with P. falciparum after treatment, compared with those without P. malariae infection.