No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

Authors
van Vugt, M Ezzet, F Nosten, F Gathmann, I Wilairatana, P Looareesuwan, S White, NJ
Citation
M. Van Vugt et al., No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine, AM J TROP M, 61(6), 1999, pp. 964-967
Citations number
16
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
61
Issue
6
Year of publication
1999
Pages
964 - 967
Database
ISI
SICI code
0002-9637(199912)61:6<964:NEOCDA>2.0.ZU;2-B
Abstract
Artemether-lumefantrine is a new fixed antimalarial combination effective a gainst multidrug-resistant falciparum malaria. A prospective electrocardiog raphic study was conducted in 150 patients receiving artemether-lumefantrin e and 50 treated with artesunate-mefloquine. There was no evidence for clin ically significant changes in the electrocardiographic intervals and in par ticular no relationship between plasma concentrations of lumefantrine and Q Tc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.