Background: The goal of this study was to determine if the combination of s
urgery and anesthesia is an independent risk factor for the development of
incident (first-time) ischemic stroke.
Methods: All residents of Rochester, MN, with incident ischemic stroke from
1960 through 1984 (1,455 cases and 1,455 age-and gender-matched controls)
were used to identify risk factors associated with ischemic stroke. Cases a
nd controls undergoing surgery involving general anesthesia or central neur
oaxis blockade before their stroke/index date of diagnosis were identified.
A conditional logistic regression model was used to estimate the odds rati
o of surgery and anesthesia for ischemic stroke while adjusting for other k
nown risk factors.
Results: There were 59 cases and 17 controls having surgery within 30 days
before their stroke/index date. After adjusting for previously identified r
isk factors, surgery within 30 days before the stroke/index date (periopera
tive period) was found to be an independent risk factor for stroke (P < 0.0
01; odds ratio, 3.9; 95% confidence interval, 2.1-7.4). In an analysis that
excluded matched pairs where the case and/or control under-went surgery co
nsidered "high risk" for stroke (cardiac, neurologic, or vascular procedure
s), "non-high-risk surgery" was also found to be an independent risk factor
for perioperative stroke (P = 0.002; odds ratio, 2.9; 95% confidence inter
val, 1,5-5,7).
Conclusion: Our results suggest that there is an increased risk of ischemic
stroke in the 30 days after surgery and anesthesia. This risk remains elev
ated even after excluding surgeries (cardiac, neurologic, and vascular surg
eries) considered to be high risk for ischemic stroke.