Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation and glandular component

Citation
V. Karpuz et al., Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation and glandular component, ANN PATHOL, 20(1), 2000, pp. 62-65
Citations number
12
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
ANNALES DE PATHOLOGIE
ISSN journal
02426498 → ACNP
Volume
20
Issue
1
Year of publication
2000
Pages
62 - 65
Database
ISI
SICI code
0242-6498(200001)20:1<62:MPNSTW>2.0.ZU;2-5
Abstract
An exceptional case of malignant peripheral nerve sheath tumor with striate d muscle differentiation and glandular component is reported, in a 52-year old man. This tumor measured 8 cm in diameter, and was localized in the che st wall, infiltrating the skeletal muscle. The mesenchymal portion of the t umor was composed mostly of spindle cells arranged in interlacing fascicles . Between these fascicles, there were large cells with abundant eosinophili c cytoplasm and clear elongated nucleus. Immunohistochemical study demonstr ated cytokeratin, EMA and CEA expression in the glandular component and S10 0 protein expression in the major portion of the mesenchymal component. The large cells identified as rhabdomyoblasts, expressed desmin, myoglobin, al pha-SR actin and alpha-SM actin. The tumor recurred 5 years after its resec tion. Histological and immunohistochemical features were identical. We thin k that positivity of neoplastic striated muscle cells with alpha-SM actin r eflects an early differentiation phase of these cells.