Heterogeneity of T-Lymphocyte function in primary progressive multiple sclerosis: Relation to magnetic resonance imaging lesion volume

Authors
Prat, A Pelletier, D Duquette, P Arnold, DL Antel, JP
Citation
A. Prat et al., Heterogeneity of T-Lymphocyte function in primary progressive multiple sclerosis: Relation to magnetic resonance imaging lesion volume, ANN NEUROL, 47(2), 2000, pp. 234-237
Citations number
13
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
47
Issue
2
Year of publication
2000
Pages
234 - 237
Database
ISI
SICI code
0364-5134(200002)47:2<234:HOTFIP>2.0.ZU;2-5
Abstract
We found that in vitro migration and interferon-gamma production by lymphoc ytes derived from primary progressive multiple sclerosis patients preselect ed on the basis of a high T2-weighted lesion volume (>10 cm(3)) on magnetic resonance imaging, were increased compared with that in primary progressiv e multiple sclerosis patients with a low T2-weighted lesion volume (<3 cm(3 )) and controls. Whether the heterogeneity of immune function within the pr imary progressive population will correlate with response to therapy remain s to be established.