Substituted indole-2-carboxylates as potent antagonists of the glycine binding site associated with the NMDA receptor

Authors
Micheli, F Di Fabio, R Baraldi, D Conti, N Cugola, A Gastaldi, P Giacobbe, S Marchioro, C Mugnaini, M Rossi, L Pecunioso, A Pentassuglia, G
Citation
F. Micheli et al., Substituted indole-2-carboxylates as potent antagonists of the glycine binding site associated with the NMDA receptor, ARCH PHARM, 332(8), 1999, pp. 271-278
Citations number
34
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
332
Issue
8
Year of publication
1999
Pages
271 - 278
Database
ISI
SICI code
0365-6233(199908)332:8<271:SIAPAO>2.0.ZU;2-#
Abstract
A novel series of indole-2-carboxylate analogues of GV 150526 (1) in which the propenoic double bond was substituted with different "probes" or replac ed by a isosteric cyclopropyl moiety were synthesized and evaluated for the ir affinity profile in order to obtain further information on the pharmacop horic model of the glycine binding site associated to the NMDA receptor.