Aims-To determine the effects of premedication with thiopental on heart rat
e, blood pressure, and oxygen saturation during semi-elective nasotracheal
intubation in neonates.
Methods-A randomised, placebo controlled, non-blinded study design was used
to study 30 neonates (mean birthweight 3.27 kg) requiring semi-elective na
sotracheal intubation. The babies were randomly allocated to receive either
6 mg/kg of thiopental (study group) or an equivalent volume of physiologic
al saline (control group) one minute before the start of the procedure. Six
infants were intubated primarily and 24 were changed from orotracheal to a
nasotracheal tube. The electrocardiogram, arterial pressure wave, and tran
scutaneous oxygen saturation were recorded continuously 10 minutes before,
during, and 20 minutes after intubation. Minute by minute measurements of h
eart rate, heart rate variability, mean blood pressure (MBP) and transcutan
eous oxygen saturation (SpO(2)) were computed. The differences for all of t
hese between the baseline measurements and those made during and after intu
bation were determined. Differences in the measurements made in the study a
nd the control groups were compared using Student's t test.
Results-During intubation, heart rate increased to a greater degree (12.0 u
s - 0.5 beats per minute, p < 0.03) and A MBP increased to a lesser degree
(-2.9 vs 4.4 mm Hg; p < 0.002) in the infants who were premedicated with th
iopental. After intubation only the changes in MBP differed significantly b
etween the two groups (-3.8 vs 4.6 mm Hg; p < 0.001). There were no signifi
cant changes in the oxygen saturation between the two groups during or afte
r intubation. The time taken for intubation was significantly shorter in th
e study group (p < 0.04).
Conclusions The heart rate and blood pressure of infants who are premedicat
ed with thiopental are maintained nearer to baseline values than those of s
imilar infants who receive no premedication. Whether this lessening of the
acute drop in the heart rate and increase in blood pressure typically seen
during intubation of unmedicated infants is associated with long term advan
tages to the infants remains to be determined.