Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

Authors
Abbenante, G Kovacs, DM Leung, DL Craik, DJ Tanzi, RE Fairlie, DP
Citation
G. Abbenante et al., Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site, BIOC BIOP R, 268(1), 2000, pp. 133-135
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
268
Issue
1
Year of publication
2000
Pages
133 - 135
Database
ISI
SICI code
0006-291X(20000205)268:1<133:IOBFBO>2.0.ZU;2-I
Abstract
A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most po tent (IC50 = 700 nM) in the series displaying an inhibitory profile which i s different from reported inhibitors of beta-amyloid formation. (C) 2000 Ac ademic Press.