METHANOL SOLVATE OF THE 11 MOLECULAR-COMPLEX OF TRIMETHOPRIM AND SULFADIMIDINE

In the title complex, C14H18N4O3.C12H14N4O2S.CH4O, the molecular assoc iation between trimethoprim ,5-trimethoxyphenyl)methyl]pyrimidine-2,4- diamine; TMP} and sulfadimidine -N-(4,6-dimethyl-2-pyrimidinyl)benzene sulfonamide; SDMD] is maintained by two N-H ... N hydrogen bonds with no proton transfer from the sulfonamide imino N atom to the pyrimidine N atom of TMP. The methanol solvate molecule is linked to an O atom o f the sulfonamido group through a strong O-H ... O interaction and doe s not seem to play an important role in the crystal-packing stabilizat ion.