Computational modeling of the baroreflex arc: Nucleus tractus solitarius

In this study, we examine the utility of computational modeling in understa nding nervous system function. We start by examining the reasons for, and m ajor approaches to, computational modeling. We then chose a modeling approa ch and applied different variations to understanding nucleus tractus solita rius (NTS) neuronal responses to various baroreceptive stimuli. We examine the results in light of our objectives and with regard to the known paramet ers of the system under investigation. Our results demonstrate that modelin g can be a useful tool in analysis of (and examination of underlying mechan isms for) NTS behavior on many levels. (C) 2000 Elsevier Science Inc.