STRUCTURAL STUDIES OF MITOMYCINS .9. 6-DEMETHYL-6-(PHENYLTHIOMETHYL)-MITOMYCIN-C

Authors
SUGAYA N FUJII I HIRAYAMA N ARAI H KASAI M
Citation
N. Sugaya et al., STRUCTURAL STUDIES OF MITOMYCINS .9. 6-DEMETHYL-6-(PHENYLTHIOMETHYL)-MITOMYCIN-C, Acta crystallographica. Section C, Crystal structure communications, 53, 1997, pp. 610-612
Citations number
8
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
53
Year of publication
1997
Part
5
Pages
610 - 612
Database
ISI
SICI code
0108-2701(1997)53:<610:SSOM.6>2.0.ZU;2-1
Abstract
The title compound, (1aS)-6-amino-8-{[(aminocarbonyl)-oxy]methyl}-1, b -hexahydro-8a-methoxy-5-(phenylthiomethyl)azirino [2',3':3,4]pyrrolo[1 ,2-a]indole-4,7-dione, C21H22N4O5S, is a C6-substituted methyl mitomyc in C which possesses potent antitumor activities. The N4 atom is more pyramidal than the corresponding atom in both mitomycin C anhydride an d mitomycin C dihydrate.