Fj. Lopez-hernandez et al., Mesenteric cyclooxygenase products after combined antihypertensive treatment in uninephrectomized SHRs, CARDIO DRUG, 14(1), 2000, pp. 41-48
Citations number
29
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Unilateral nephrectomy in the spontaneously hypertensive rat (SHR) does not
produce any change in blood pressure but does induce humoral alterations t
hat might influence the antihypertensive action of some drugs. In this stud
y, the antihypertensive effect of treatment (5 weeks) with placebo (control
), verapamil, trandolapril, or their combination (verapamil plus trandolapr
il) was investigated in SHRs with half renal mass ablation, regarding the s
tructure and function of small mesenteric arteries. Arterial pressure was f
ollowed during the period of treatment. Trandolapril and veratran returned
pressure to normal, while verapamil was ineffective. Statistically signific
ant differences in the parameters of vessel structure were not observed amo
ng groups; thus, the alterations in functionality cannot be attributed to m
orphologic changes. The noradrenaline-induced contraction was reduced simil
arly by the three treatments as compared to controls. This difference invol
ved a higher participation of nitric oxide in the trandolapril group, while
in the verapamil group the origin of the difference might be due to the ab
olishment of a cyclooxygenase product. Veratran retained both effects. Acet
ylcholine-evoked relaxation of vessels precontracted with noradrenaline was
improved with treatments versus controls. The abolishment of a contracting
prostanoid or an NO scavenger from the cyclooxygenase pathway, due to the
treatments implemented, is probably the cause of this.