H. Senoo et al., Vitamin A-storing system in mammals and birds in Arctic area - A study in the Svalbard archipelago-, CELLS OF THE HEPATIC SINUSOID, VOL 7, 1999, pp. 34-35
Arctic animals such as polar bears (Ursus maritimus), polar foxes (Alopex l
agopus), bearded seals (Erignathus barbatus), ringed seals (Phoca hispida),
Svalbard reindeers (Rangifer tarandus platyrhynchus), glaucous gulls (Laru
s hyperboreus), Brunnich's guillemots (Uria lomvia), and puffins (Fratercul
a arctica) store a large amount of vitamin A (retinyl ester) in hepatic ste
llate cells (interstitial cells, lipocytes, fat-storing cells, Ito cells),
compared to human or usual experimental animals like rat or mouse. Other or
gans, namely, kidney, intestine, muscle, spleen, and lung store only a smal
l amount of vitamin A. These animals show neither hypervitaminosis A signs
and symptoms nor pathological findings in the liver.