Microsatellites and minisatellites are the most informative molecular genet
ic markers and dispersed throughout the genome. Methylation of cytosine and
adenine residues is associated with various biological phenomena. We show
the microsatellite and minisatellite loci in rice to be methylated differen
tially in various rice cultivars. We propose that few of these differential
methylations might be associated with the morphological variations observe
d in rice cultivars and wild rice species. Since microsatellites and minisa
tellites have been suggested to be hot spots of recombination, these methyl
ations in general could be involved in maintaining genome stability by supp
ressing the high levels of recombination.