The use of cyclodextrin and their derivatives as stationary phases for separation of enantiomers by capillary gas chromatography

The review deals with the use of cyclodextrins (CD) and their derivatives a s stationary phases in gas chromatography for separation of enantiomers of organic substances. Unlike the native cyclodextrins, their alkyl, acyl and tert-butyl(tri-methyl)silyl derivatives are successfully used as stationary phases in capillary gas chromatography. The enantioselectivity of the CD d erivatives can be changed both by the nature of silyl substituents and by t he type of CDs. alpha-, beta- and gamma-CD derivatives with bulkier substit uents in positions 2 and 3 than in position 6 exhibit a specific enantiosel ectivity compared with those containing equal substituents.