Cytochrome P450-mediated drug interactions

Authors
Flockhart, DA Oesterheld, JR
Citation
Da. Flockhart et Jr. Oesterheld, Cytochrome P450-mediated drug interactions, CH ADOLESC, 9(1), 2000, pp. 43
Citations number
185
Categorie Soggetti
Psychiatry
Journal title
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
ISSN journal
10564993 → ACNP
Volume
9
Issue
1
Year of publication
2000
Database
ISI
SICI code
1056-4993(200001)9:1<43:CPDI>2.0.ZU;2-4
Abstract
This article reviews hepatic P450-drug-metabolizing cytochromes (CYPs). Sta rting with the nomenclature and development of CYPs, the authors discuss co ncepts necessary to understand clinically relevant CYP-based drug interacti ons, polymorphisms, substrates, inhibitors, and inducers of CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and the CYP3A subfamily are reviewed. Case histor ies, CYP lists, and CYP websites are provided to highlight drug interaction s relevant to child psychiatrists.