Although autopsy studies reveal significant pancreatic lesions in abou
t 10% of AIDS patients, pancreatic lesions infrequently produce sympto
ms and are rarely recognized premortem. Patients with AIDS can develop
pancreatic disease from causes not related to AIDS or AIDS-specific l
esions. AIDS-specific causes include opportunistic infection, AIDS-ass
ociated neoplasia, and medications used to treat complications of AIDS
. Pancreatic involvement is usually part of a widely disseminated tumo
r and rarely produces clinical symptoms.