Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis

Authors
Schmid, MG Laffranchini, M Dreveny, D Gubitz, G
Citation
Mg. Schmid et al., Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis, ELECTROPHOR, 20(12), 1999, pp. 2458-2461
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
ELECTROPHORESIS
ISSN journal
01730835 → ACNP
Volume
20
Issue
12
Year of publication
1999
Pages
2458 - 2461
Database
ISI
SICI code
0173-0835(199908)20:12<2458:CSOSBL>2.0.ZU;2-H
Abstract
A rapid and simple approach to the chiral separation of sympathomimetic dru gs with amino alcohol structure by ligand exchange capillary electrophoresi s is described. An N-(2-hydroxyoctyl)-L-4-hydroxyproline/copper(II) complex is used as chiral selector. Thirteen sympathomimetics were resolved, nine with baseline resolution. The influence of pH and composition of the electr olyte on resolution was investigated. The optimal pH for complexation of th ese amino alcohols was found to be 12.