Employees at a health center in Georgia were concerned that symptoms experi
enced by some employees were related to pesticide exposure at the center. M
alathion and DDT, used for mosquito control from 1969 to 1981, had been sto
red and handled at the center's first floor. We surveyed 117 (91%) of 129 e
mployees to determine whether reported symptoms were associated with pestic
ide exposure. We performed environment al sampling for pesticides. We analy
zed serum samples for 17 chlorinated pesticides, and urine samples for mala
thion. We found that 37% of the participants had reported a diagnosis of si
nusitis and 24% of bronchitis since working at the health center, Frequentl
y reported symptoms were eye irritation (44%) and headache (68%), DDT and m
alathion were found at levels of 2.4 and 11%, respectively, in bulk samples
from the loading dock of the building. Multivariate analysis of responses
to the questionnaire showed that the perception of odors, inadequate air ho
w, and length of employment were significantly associated with the employee
s' health complaints. Pesticide concentrations in employees' serum and urin
e samples were not associated with any health complaint, The health complai
nts reported by the employees at the health center were precipitated by bot
h environmental and psychological factors. The epidemiology and laboratory
components of this study highlight the importance of obtaining biological m
easurements in episodes of perceived environmental exposure.