No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study

Authors
Goodwin, H Curran, N Chioza, B Blower, J Nashef, L Asherson, P Makoff, AJ
Citation
H. Goodwin et al., No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study, EPILEPSY R, 39(1), 2000, pp. 27-31
Citations number
28
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
EPILEPSY RESEARCH
ISSN journal
09201211 → ACNP
Volume
39
Issue
1
Year of publication
2000
Pages
27 - 31
Database
ISI
SICI code
0920-1211(200003)39:1<27:NAFBPI>2.0.ZU;2-O
Abstract
The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control associati on studies performed on DNA from more than 100 patients with idiopathic gen eralised epilepsy (IGE). No significant association was found with IGE for either polymorphism. (C) 2000 Published by Elsevier Science B.V. All rights reserved.