CARDIOVASCULAR EFFECTS OF ENDOTHELIN

Authors
GROSSMAN JD MORGAN JP
Citation
Jd. Grossman et Jp. Morgan, CARDIOVASCULAR EFFECTS OF ENDOTHELIN, News in physiological sciences, 12, 1997, pp. 113-117
Citations number
14
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
12
Year of publication
1997
Pages
113 - 117
Database
ISI
SICI code
0886-1714(1997)12:<113:CEOE>2.0.ZU;2-Y
Abstract
Endothelin is a potent vasoconstricting agent released by vascular end othelial cells. Endothelin affects multiple organ systems and occurs a t high levels with heart disease. Changes in cellular calcium levels a nd Ca2+ sensitization of myofilaments mediate the endothelin pathway. The ability to modulate endothelin levels may lead to many effective t herapies.