GABA(C) RECEPTORS - A NOVEL RECEPTOR FAMILY WITH UNUSUAL PHARMACOLOGY

GABA(C)-receptor channels constitute a novel class of structurally def ined receptors that are composed by the recently discovered rho-subuni ts. They conduct chloride ions, are insensitive to both bicuculline an d baclofen, and are blocked by picrotoxin. They are present in the hip pocampus during development and in the retina where they play a crucia l role in regulating visual processing.