Successful induction of ovulation using highly purified follicle-stimulating hormone in a woman with Kallmann's syndrome

Objective: To describe a woman with Kallmann's syndrome who was treated suc cessfully with highly purified FSH to achieve ovulation induction and pregn ancy. Design: Case report. Setting: University hospital. Patient(s): A 32-year-old woman with Kallmann's syndrome who had been treat ed with oral contraceptives to prime secondary sex characteristics and geni tal organs since the age of 16 years. Intervention(s): Highly purified FSH was administered intramuscularly for a total dose of 3,825 IU. Main Outcome Measure(s): Follicle number and diameter. Result(s): Three follicles with a diameter of >1.7 cm and an endometrial th ickness of 8 mm were observed. A clinical pregnancy, which subsequently was spontaneously aborted, was obtained. Conclusion(s): In primed patients with Kallmann's syndrome, highly purified FSN may be a useful alternative to pulsatile GnRH or menopausal gonadotrop ins to achieve ovulation induction and pregnancy. (Fertil Steril(R) 2000;73 :284-6. (C) 2000 by American Society for Reproductive Medicine.)