A finite element model for simulating acoustic streaming in cystic breast lesions with experimental validation

Citation
Kr. Nightingale et Ge. Trahey, A finite element model for simulating acoustic streaming in cystic breast lesions with experimental validation, IEEE ULTRAS, 47(1), 2000, pp. 201-215
Citations number
27
Categorie Soggetti
Optics & Acoustics
Journal title
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
ISSN journal
08853010 → ACNP
Volume
47
Issue
1
Year of publication
2000
Pages
201 - 215
Database
ISI
SICI code
0885-3010(200001)47:1<201:AFEMFS>2.0.ZU;2-3
Abstract
Streaming detection is an ultrasonic technique that can be used to distingu ish fluid-filled lesions, or cysts, from solid lesions. With this technique , high intensity ultrasound pulses are used to induce acoustic streaming in cyst fluid, and this motion is detected using Doppler flow estimation meth ods. Results from a pilot clinical study were recently published in which a coustic streaming was successfully induced and detected in 14 of 15 simple breast cysts and four of 14 sonographically indeterminate breast lesions in vivo. In this study, the detected velocities were found to vary considerab ly among cysts and for different pulsing regimes. A finite element model of streaming detection is presented in this paper. T his model is utilized to investigate methods of increasing induced acoustic streaming velocity while minimizing patient exposure to high intensity ult rasound during streaming detection. Parameters studied include intensity, f requency, acoustic beam shape, cyst diameter, cyst fluid protein concentrat ion, and cyst fluid viscosity. The model, which provides both transient and steady-state solutions, is shown to predict trends in streaming velocity a ccurately. Experimental results from studies investigating the potential fo r nonlinear streaming enhancement in cysts are also provided.