Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

Authors
Tak, PP Zvaifler, NJ Green, DR Firestein, GS
Citation
Pp. Tak et al., Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases, IMMUNOL TOD, 21(2), 2000, pp. 78-82
Citations number
49
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
2
Year of publication
2000
Pages
78 - 82
Database
ISI
SICI code
0167-5699(200002)21:2<78:RAAPHO>2.0.ZU;2-W
Abstract
Oxidative stress at sites of chronic inflammation can cause permanent genet ic changes. The development of mutations in the p53 tumor suppressor gene a nd other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.