Oral androstenedione administration and serum testosterone concentrations in young men

Context Androstenedione, a steroid hormone and the major precursor to testo sterone, is available without prescription and is purported to increase str ength and athletic performance. The hormonal effects of androstenedione, ho wever, are unknown. Objective To determine if oral administration of androstenedione increases serum testosterone levels in healthy men. Design Open-label randomized controlled trial conducted between October 199 8 and April 1999. Setting General clinical research center of a tertiary-care, university-aff iliate hospital. Participants Forty-two healthy men aged 20 to 40 years, Intervention Subjects were randomized to receive oral androstenedione (eith er 100 mg/d [n = 15] or 300 mg/d [n = 14]) or no androstenedione (n = 13) f or 7 days. Main Outcome Measures Changes in serum testosterone, androstenedione, estro ne, and estradiol levels, measured by frequent blood sampling, compared amo ng the 3 treatment groups. Results Mean (SE) changes in the area under the curve (AUC) for serum testo sterone concentrations were -2% (7%), -4% (4%), and 34% (14%) in the groups receiving 0, 100, and 300 mg/d of androstenedione, respectively. When comp ared with the control group, the change in testosterone AUC was significant for the 300-mg/d group (P<.001) but not for the 100-mg/d group (P = .48). Baseline testosterone levels, drawn 24 hours after androstenedione administ ration, did not change. Mean (SE) changes in the AUC for serum estradiol co ncentrations were 4% (6%), 42% (12%), and 128% (24%) in the groups receivin g 0, 100, and 300 mg/d of androstenedione, respectively. When compared with the control group, the change in the estradiol AUC was significant for bot h the 300-mg/d (P<.001) and 100-mg/d (P = .002) groups. There was marked va riability in individual responses for all measured sex steroids. Conclusions Our data suggest that oral androstenedione, when given in dosag es of 300 mg/d, increases serum testosterone and estradiol concentrations i n some healthy men.