IL-8, IL-6 and ICAM-1 in serum of paediatric patients undergoing cardiopulmonary bypass with and without cardiocirculatory arrest

Background. The aim of the present study was to evaluate the systemic infla mmatory response to CPB in paediatric patients undergoing surgical correcti on of congenital heart diseases. Methods. Experimental design: comparative investigation, Setting: paediatri c cardiology hospital. Intervention: ICAM-1, IL-8, and IL-6 production were analysed before and during CPB, and after surgery in 9 paediatric patients , submitted to cardiocirculatory arrest (Group A); and in 11 without cardio circulatory arrest (Group B), Measures: ICAM-1, IL-8, and IL-6 production w ere analysed from arterial samples before and during CPB, and after surgery . Results, In group A vs group B a significant increase of IL-8 was detected during (297+/-250 vs 11+/-19 pg.ml(-1), p<0.001) and after (100+/-230 us n. d. pg.ml(-1)) surgery and was correlated with the duration of operation (r= 0.759; p=0.0001) and clamping time (r=0.738; p<0.05), After surgery in grou p A, IL-6 levels (35+/-43 pg ml) were higher than those in group B (2+/-5 p g ml), and a good correlation was observed between IL-6 and duration of aor tic clamping (r=0.714; p=0.048), cardiac arrest, (r=0.714; p=0.048), and le ngth of surgery (r=0.867; p=0.04). Conclusions In children who underwent CPB with cardiocirculatory arrest cyt okine production seems related to duration of operation and amplified by is chemia-reperfusion phenomena.