A 2.8 MEGABASE YAC CONTIG SPANNING D8S339, WHICH IS TIGHTLY LINKED TOTHE WERNER-SYNDROME LOCUS

Authors
BRUSKIEWICH R SCHERTZER M WOOD S
Citation
R. Bruskiewich et al., A 2.8 MEGABASE YAC CONTIG SPANNING D8S339, WHICH IS TIGHTLY LINKED TOTHE WERNER-SYNDROME LOCUS, Genome, 40(1), 1997, pp. 77-83
Citations number
33
Categorie Soggetti
Genetics & Heredity
Journal title
Genome → ACNP
ISSN journal
08312796
Volume
40
Issue
1
Year of publication
1997
Pages
77 - 83
Database
ISI
SICI code
0831-2796(1997)40:1<77:A2MYCS>2.0.ZU;2-B
Abstract
A number of gene loci, including the locus for Werner syndrome (WRN), map to proximal human chromosome 8p near the genetic marker D8S339. In this report, we present a long range physical map of an approximately 2.8 megabase yeast artificial chromosome contig centred on D8S339. In this map, we localize the WRN-linked polymorphic sequence-tagged site s (STS) D8S339 and D8S1055, as well as a novel polymorphic STS, D8S229 7. We also refine the positions of three known gene loci, GTF2E2, GSR, and PPP2CB, relative to the location of WRN within the map.