Pathology of the bone-implant interfaces

Citation
N. Al-saffar et Pa. Revell, Pathology of the bone-implant interfaces, J LONG-TE E, 9(4), 1999, pp. 319-347
Citations number
187
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF LONG-TERM EFFECTS OF MEDICAL IMPLANTS
ISSN journal
10506934 → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
319 - 347
Database
ISI
SICI code
1050-6934(1999)9:4<319:POTBI>2.0.ZU;2-T
Abstract
Joint replacement surgery has a wide clinical application as a successful t echnique. However, the release of biomaterial in particulate form from vari ous implant components has been implicated as a cause of two major clinical complications: 1)bone lysis with or without aseptic loosening, and 2) diss emination of wear particles to distant sites with adverse local or systemic cellular responses. This review focuses on the analysis of the clinical ma terial obtained at the time of revision operations and its value in identif ying the pathological processes taking place within the bone-implant microe nvironment. Important issues discussed include the incidence of infection, characterization of wear particles, particle-cell interactions, local histo pathological changes that lead to the formation of erosive inflammatory les ions next to the bone, sensitivity reactions, tumor formation, and the indu ction of inflammatory factors and cytokines that can influence the rate of bone resorption versus bone formation.