Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis

Authors
Wellington, KD Cambie, RC Rutledge, PS Bergquist, PR
Citation
Kd. Wellington et al., Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis, J NAT PROD, 63(1), 2000, pp. 79-85
Citations number
25
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
1
Year of publication
2000
Pages
79 - 85
Database
ISI
SICI code
0163-3864(200001)63:1<79:COS1NB>2.0.ZU;2-T
Abstract
Seven-new compounds (1-6 and 10) with a unique carbon skeleton have been is olated from the sponge Hamigera tarangaensis, and the structure of a previo usly reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3-6 showed moderat e in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus i nhibition against both the Herpes and Polio viruses, with only slight cytot oxicity.