A cytotoxic 5 alpha,8 alpha-epidioxysterol from a soft coral Sinularia species

Authors
Sheu, JH Chang, KC Duh, CY
Citation
Jh. Sheu et al., A cytotoxic 5 alpha,8 alpha-epidioxysterol from a soft coral Sinularia species, J NAT PROD, 63(1), 2000, pp. 149-151
Citations number
20
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
1
Year of publication
2000
Pages
149 - 151
Database
ISI
SICI code
0163-3864(200001)63:1<149:AC5AAF>2.0.ZU;2-8
Abstract
A new sterol, (22R,23R,24R)-5 alpha,8 alpha-epidioxy-22,23-methylene-24-met hylcholest-6-en-3 beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp . The structure of metabolite 1 was determined by spectral analysis. Cytoto xicity of sterols 1-3 toward various cancer cell lines is also reported.