Expression and cellular localization of the urokinase-type plasminogen activator and its receptor in human hepatocellular carcinoma

Authors
Dubuisson, L Monvoisin, A Nielsen, BS Le Bail, B Bioulac-Sage, P Rosenbaum, J
Citation
L. Dubuisson et al., Expression and cellular localization of the urokinase-type plasminogen activator and its receptor in human hepatocellular carcinoma, J PATHOLOGY, 190(2), 2000, pp. 190-195
Citations number
20
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF PATHOLOGY
ISSN journal
00223417 → ACNP
Volume
190
Issue
2
Year of publication
2000
Pages
190 - 195
Database
ISI
SICI code
0022-3417(200002)190:2<190:EACLOT>2.0.ZU;2-M
Abstract
The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion, Previous studies have shown by RT-PC R that uPA and mRNAs are expressed in human hepatocellular carcinoma (WCC). Here, in situ hybridization, immunohistochemistry, and double immunofluore scence were used to identify the cells expressing uPA and uPAR in 26 HCCs, The results indicate that uPA and uPAR were expressed in every case, almost exclusively in stromal cells, mostly myofibroblasts and macrophages, excep t for rare tumoural hepatocytes expressing cytokeratin 7, These results sho w the important role of stromal cells of HCC in the pericellular proteolysi s which facilitates cancer cell invasion. Copyright (C) 2000 John Wiley & S ons, Ltd.