PROGRESS IN PROTEIN-STRUCTURE PREDICTION

If protein structure prediction methods are to make any impact on the impending onerous task of analyzing the large numbers of unknown prote in sequences generated by the ongoing genome-sequencing projects, it i s vital that they make the difficult transition from computational 'ge dankenexperiments' to practical software tools. This has already happe ned in the field of comparative modelling and is currently happening i n the threading field. Unfortunately, there is little evidence of this transition happening in the field of ab initio tertiary-structure pre diction. (C) Current Biology Ltd.