Authors
Citation
Ao. Hueber, CD95: more than just a death factor?, NAT CELL BI, 2(2), 2000, pp. E23-E25
Citations number
15
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392
→ ACNP
Volume
2
Issue
2
Year of publication
2000
Pages
E23 - E25
Database
ISI
SICI code
1465-7392(200002)2:2<E23:CMTJAD>2.0.ZU;2-H
Abstract
The CD95 protein delivers crucial signals for lymphocyte death, and may als
o negatively regulate T-lymphocyte activation by preventing the influx of c
alcium ions from the cell's exterior. The block in calcium-ion influx occur
s through the activation of acidic sphingomyelinase and the release of cera
mide, a metabolite that can also induce cell death.