Central diabetes insipidus preceding acute myeloid leukemia with t(3;12)(q26;p12)

A 52-year-old woman presented with polyuria and polydipsia. ii diagnosis of central diabetes insipidus (DI) was made, which turned out to be the first sign of acute myeloid leukemia (AML). Cytogenetic analysis revealed a bala nced translocation between chromosome 3 and 12 t(3;12)(q26;p12). The patien t was treated with standard induction chemotherapy and vasopressin. Before consolidation chemotherapy could be administered, deep venous thrombosis wa s diagnosed and leukemia relapsed. Rescue chemotherapy was started. This is the first report of an association between AML with t(3;12) and DI. Its po ssible pathogenesis is discussed with a review of the literature. (C) 2000 Elsevier Science B.V. All rights reserved.