Genetic analysis of vitamin D related genes in Canadian multiple sclerosispatients

Authors
Steckley, JL Dyment, DA Sadovnick, AD Risch, N Hayes, C Ebers, GC
Citation
Jl. Steckley et al., Genetic analysis of vitamin D related genes in Canadian multiple sclerosispatients, NEUROLOGY, 54(3), 2000, pp. 729-732
Citations number
7
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
3
Year of publication
2000
Pages
729 - 732
Database
ISI
SICI code
0028-3878(20000208)54:3<729:GAOVDR>2.0.ZU;2-U
Abstract
The objective of this study was to investigate genes involved in the metabo lism and function of vitamin D as candidate genes for genetic susceptibilit y to MS. Restriction fragment length polymorphisms and highly polymorphic m icrosatellite markers within or very close to the 1,25(OH)(2)D-3 receptor ( VDR) [12q14], the vitamin D binding protein (DBP) [4q12], and the 25(OH)D-3 1 alpha-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.