AIDS- and non-AIDS-related PML association with distinct p53 polymorphism

Authors
Power, C Gladden, JGB Halliday, W Del Bigio, MR Nath, A Ni, W Major, EO Blanchard, J Mowat, M
Citation
C. Power et al., AIDS- and non-AIDS-related PML association with distinct p53 polymorphism, NEUROLOGY, 54(3), 2000, pp. 743-746
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
3
Year of publication
2000
Pages
743 - 746
Database
ISI
SICI code
0028-3878(20000208)54:3<743:AANPAW>2.0.ZU;2-6
Abstract
A population-based analysis of progressive multifocal leukoencephalopathy ( PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% amon g patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosi ty (Arg-Pro) at codon 72 in five of six PML patients. These findings indica te that frequencies of non-AIDS- and AIDS-related PML differ markedly but p 53 polymorphisms may influence the occurrence of PML in both groups.